Breast adenocarcinoma MCF-7 cell line response to 27-Hydroxycholesterol and estradiol
Summary:
Analysis of MCF-7 cells treated with 27HC in the presence of E2. 27HC, a primary metabolite of cholesterol and an estrogen receptor (ER) ligand, increases ER-dependent growth in mouse models of breast cancer. Results provide insight into a relationship between hypercholesterolemia and breast cancer.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Nelson ER, Wardell SE, Jasper JS, Park S et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 2013 Nov 29;342(6162):1094-8. PMID: 24288332
