H3K4me3 histone demethylase Fbxl10 overexpression effect on fibroblast cell line
Summary:
Analysis of MEF cell line stably overexpressing Fbxl10. Stable overexpression of Fbxl10 leads to an increase in cell size but no changes to proliferation, mitosis, apoptosis, or global histone marks. Results provide insight into the regulatory role of Fbx110 in fibroblasts.
Janzer A, Stamm K, Becker A, Zimmer A et al. The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts. J Biol Chem 2012 Sep 7;287(37):30984-92. PMID: 22825849
