Transcription factor treatment effect on embryonic fibroblasts
Summary:
Analysis of embryonic fibroblasts transduced with various transcription factor combinations (MEF2C, TBX5, NKX2.5, GATA4, Hand2, MYOCD) to drive transdifferentiation to induced cardiomyocytes (iCMs). Results provide insight into molecular mechanisms governing direct fibroblast reprogramming to iCMs.
Addis RC, Ifkovits JL, Pinto F, Kellam LD et al. Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. J Mol Cell Cardiol 2013 Jul;60:97-106. PMID: 23591016