Analysis of liver from Casp1-null, C57BL/6 males in a fasted state. Caspase-1 is a cysteine protease that activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS6176, provide insight into the role of caspase-1 in lipid metabolism.
van Diepen JA, Stienstra R, Vroegrijk IO, van den Berg SA et al. Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion. J Lipid Res 2013 Feb;54(2):448-56. PMID: 23160218
