SW480 KRAS-mutant colorectal cancer cell line response to dual inhibition of tankyrase and MEK: time course
Summary:
Analysis of SW480 cancer cells treated with tankyrase inhibitor, MEK inhibitor, or both, for up to 16hrs. Dual inhibition of TNKS and MEK led to tumor regression. Results provide insight into molecular mechanisms underlying the synergistic effects of TNKS and MEK inhibitors in KRAS-mutant cancers.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Schoumacher M, Hurov KE, Lehár J, Yan-Neale Y et al. Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling. Cancer Res 2014 Jun 15;74(12):3294-305. PMID: 24747911
