Diabetes and Obesity Regulated gene abalation effect on skeletal muscle
Summary:
Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; Tp53inp2) knockout line (SKM-KO). Deletion of DOR results in muscle hypertrophy. Results provide insight into the functional role of DOR in skeletal muscle.
Sala D, Ivanova S, Plana N, Ribas V et al. Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. J Clin Invest 2014 May;124(5):1914-27. PMID: 24713655
