Oligooxopiperazine effect on hypoxic alveolar adenocarcinoma cell line
Summary:
Analysis of hypoxic A549 cells treated with oligooxopiperazines (OOPs) BB2-125, BB2-162, and BB2-282. OOPs are designed mimics of a key α-helical domain at the interface of hypoxia-inducible factor 1α (HIF1α) and coactivator p300. Results provide insight into the effect of OOPs on HIF signaling.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Lao BB, Grishagin I, Mesallati H, Brewer TF et al. In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics. Proc Natl Acad Sci U S A 2014 May 27;111(21):7531-6. PMID: 24821806
