Histone methyltransferase MMSET overexpression effect on KMS11 multiple myeloma cell line
Summary:
Analysis of KMS11 t(4;14) MM parental cell line with a normal overexpressed multiple myeloma SET domain containing protein (MMSET) and cell lines knocked out for MMSET on the translocated allele (TKO) or on the non-translocated allele (NTKO). Results provide insight into role of MMSET in t(4;14) MM.
Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet 2014 Sep;10(9):e1004566. PMID: 25188243
