Bicaudal C homolog 1 knock down effect in primary calvarial osteoblasts
Summary:
Analysis of calvarial osteoblasts transfected with siRNAs targeting bicaudal C homolog 1 (constructs BICC1_1, BICC1_2 and BICC1_3). Bicc1 encodes an RNA-binding protein. Results provide insight into the role of Bicc in osteoblastogenesis.
Mesner LD, Ray B, Hsu YH, Manichaikul A et al. Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density. J Clin Invest 2014 Jun;124(6):2736-49. PMID: 24789909