Heat shock protein 90 inhibitor effect on Huntington’s disease model: brain striatum
Summary:
Analysis of R6/2 Huntington’s disease (HD) model treated with 12mg/kg HSP990 for 4h. HSP990, a brain-penetrant HSP90 inhibitor, activates heat shock response (HSR) and alters HD-related phenotypes. Results provide insight into molecular mechanisms underlying impaired HSR-mediated HD progression.
Labbadia J, Cunliffe H, Weiss A, Katsyuba E et al. Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease. J Clin Invest 2011 Aug;121(8):3306-19. PMID: 21785217
