miR-483 overexpression effect on IGF2 expressing sarcoma cell line
Summary:
Analysis of MHH-ES-1 Ewing's sarcoma cells overexpressing miR-483. Ewing's sarcoma is an aggressive pediatric tumor expressing endogenous IGF2. miR-483-5p is embedded within the IGF2 gene. Results provide insight into the role of miR-483 in IGF2 expression.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Liu M, Roth A, Yu M, Morris R et al. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev 2013 Dec 1;27(23):2543-8. PMID: 24298054
