Embryonic kidney cell line response to depletion of H1.2 linker histone, Cul4A E3 ubiquitin ligase or PAF1 elongation complex
Summary:
Analysis of 293T cells upon depletion of H1.2, Cul4A or PAF1. Results provide insight into the molecular basis of cooperative functions of H1.2, Cul4A, and PAF1 in regulating gene transcription.
Kim K, Lee B, Kim J, Choi J et al. Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation. Cell Rep 2013 Dec 26;5(6):1690-703. PMID: 24360965