Mek1 Mek2 double mutation effect on the embryonic brain dorsal cortex
Summary:
Analysis of brain dorsal cortices of E18.5 embryos deleted for Mek1 and Mek2, dual specificity kinases. Mek1 and Mek2 are components of the RAF/MEK/ERK singaling pathway. Results provide insight into the role of Mek1 and Mek2 in gliogenesis.
Li X, Newbern JM, Wu Y, Morgan-Smith M et al. MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron 2012 Sep 20;75(6):1035-50. PMID: 22998872
