Dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines
Summary:
Analysis of dasatinib-resistant and dasatinib-sensitive PC cell lines. Dasatinib, a small-molecule kinase inhibitor, is FDA-approved for PC, but certain PC cells can have intrinsic or acquired resistance to dasatinib. Results provide insight into molecular basis of dasatinib-resistance in PC cells.
Chien W, Sun QY, Lee KL, Ding LW et al. Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. Mol Oncol 2015 Apr;9(4):889-905. PMID: 25637283
