Analysis of papillary thyroid carcinoma (TPOCreER; BrafV600E) and anaplastic thyroid carcinoma (TPOCreER; BrafV600E; p53 -/-) tumors. BRAF and TP53 mutations co-occur often in ATCs, especially those with a precursor PTC. Results provide insight into the molecular basis of PTC to ATC progression.
McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R et al. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci U S A 2014 Apr 22;111(16):E1600-9. PMID: 24711431