Anti-leukemia drug etoposide effect on ecotropic viral integration site 1-overexpressing myeloid cells
Summary:
Analysis of myeloid cell line U937 overexpressing ecotropic viral integration site 1 (EVI1) and cultured in the presence of antileukemic drug etoposide. Results provide insight into molecular mechanisms through which EVI1 confers resistance to drugs used in myeloid leukemia therapy.
GPL11532:
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Citation:
Rommer A, Steinmetz B, Herbst F, Hackl H et al. EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells. PLoS One 2013;8(2):e56308. PMID: 23457546
