show Abstracthide AbstractHidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown origin that usually develops in skin folds such as the inguinal and axillary regions. The etiology of the disease is complex and involves a combination of factors such as the environment, lifestyle, hormone imbalances, genetics and last but not least the microbiota. While bacterial skin dysbiosis is a frequently described event in the pathophysiology of HS, the link with the skin virota is largely unknown. In the present study, we aim to investigate the potential role of the skin virome in HS patients to deepen our understanding of the microbiome in this debilitating disease.