5UFP: Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex

PDB ID: 5UFPDownload
MMDB ID: 146866
PDB Deposition Date: 2017/1/5
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 5UFP: dimeric; determined by author
Molecular Components in 5UFP
Label Count Molecule
Proteins (2 molecules)
1
Endothelial PAS Domain-containing Protein 1
(Gene symbol: EPAS1)
Molecule annotation
1
Aryl Hydrocarbon Receptor Nuclear Translocator
(Gene symbol: ARNT)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303