7M05: CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988

PDB ID: 7M05Download
MMDB ID: 200016
PDB Deposition Date: 2020
Updated in MMDB: 2021/08
Experimental Method:
electron microscopy
Resolution: 2.39  Å
Source Organism:
Similar Structures:
Biological Unit for 7M05: octameric; determined by author
Molecular Components in 7M05
Label Count Molecule
Proteins (8 molecules)
4
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
4
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303