CASRN: 179474-81-8
Drug Levels and Effects
Summary of Use during Lactation
No published experience exists with prucalopride during breastfeeding. However, the manufacturer reports an unpublished study that indicates a relatively low amount of drug in breastmilk. Until more data become available, monitor the breastfed infant for diarrhea.
Drug Levels
Maternal Levels. The manufacturer reports an unpublished study in 8 healthy lactating women who were weaning their infants and given prucalopride 2 mg daily for 4 days. Plasma and milk samples were collected at predose (day 1 and 4), and at 2, 4, 8, 12, and 24 hours after the dose on day 4. The dose to the breastfed infant was estimated to be 1.74 mcg/kg daily, which is about 6% of the weight-adjusted maternal dose.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Substance Identification
Substance Name
Prucalopride
CAS Registry Number
179474-81-8
Drug Class
Breastfeeding
Lactation
Gastrointestinal Agents
Laxatives
Serotonin 5-HT4 Receptor Agonists
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Publication Details
Publication History
Last Revision: July 20, 2020.
Copyright
Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Publisher
National Institute of Child Health and Human Development, Bethesda (MD)
NLM Citation
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Prucalopride. [Updated 2020 Jul 20].