| PHARMACOKINETIC ENHANCERS (2017) | |||||
|---|---|---|---|---|---|
| Pharmacokinetic Enhancer | Primary Agent | Brand Name | Enzyme Inhibited | Year Approved | Likelihood Score† |
| Carbidopa | Levodopa | Sinemet | L-amino acid decarboxylase | 1975 | E |
| Clavulanic acid | Amoxicillin | Augmentin | Beta-lactamase | 1984 | A* |
| Clavulanic acid | Ticarcillin | Timentin | Beta-lactamase | 1985 | A* |
| Tazobactam | Piperacillin | Zosyn | Beta-lactamase | 1985 | E* |
| Cilastatin | Imipenem | Primaxin | Dehydropeptidase 1 | 1985 | D |
| Sulbactam | Ampicillin | Unasyn | Beta-lactamase | 1986 | C |
| Ritonavir‡ | Lopinavir | Kaletra | CYP 3A4 | 1996 | D |
| Ritonavir‡ | Paritaprevir | Viekira Pak | CYP 3A4 | 2015 | E* |
| Cobicistat‡‡ | Elvitegravir | Stribild, Genvoya | CYP 3A4 | 2012 | E |
| Cobicistat‡‡ | Atazanavir | Evotaz | CYP 3A4 | 2015 | D |
| Cobicistat‡‡ | Darunavir | Prezcobix | CYP 3A4 | 2015 | E* |
| Tipiracil | Trifluridine | Lonsurf | Thymidine phosphorylase | 2015 | E |
| Avibactam | Ceftazidime | Ayvcaz | Beta-lactamase | 2015 | E |
From: Pharmacokinetic Enhancers
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