Table 25GRADE Summary of Findings for HRQoL

Outcome, Follow-up, no. participants (trials) Findings Certainty of the evidence (GRADE) What happens?
HRQoL

Post-intervention: 84 (1 RCT 50 )

Longest follow-up: 84 (1 RCT 50 )

One RCT50 with high risk of bias (unclear direction) reported on participants’ HRQoL. It compared the effectiveness of HOP program to treatment as usual among adolescent psychiatric patients, who were mostly were female (69.3%), born in Germany (94.8%) and were around 22 months since the first psychiatric diagnosis.

The outcome was assessed by KIDSCREEN 1056, a 10-item questionnaire in which the total score ranges from 10 to 50 with higher scores indicating better quality of life.56,57

At post-intervention, results suggested that there may be little to no difference in the effect of peer support on HRQoL compared to treatment as usual. (Mean between-group difference for change from baseline =0.82 [95% CI –1.34 to 2.98]).

At the 6-week follow-up assessment, the results suggested that HOP may be favoured compared to treatment as usual in improving HRQoL. The mean between-group difference for change from baseline to 6 week follow-up was 3.54 (95% CI, 1.14 to 5.93).

 Very low

due to serious concerns for risk of bias, concerns for inconsistency, serious concerns for indirectness and imprecision.a

There may be little to no difference in the effect of HOP vs. TAU on HRQoL post-intervention, but the evidence is very uncertain.

HOP may be favoured vs. TAU with respects to attitudes to disclosure at longest follow-up but the evidence is very uncertain.

HOP= Honest, Open, Proud; HOP-C = Honest, Open, Proud–College; HRQoL = health-related quality of life; RCT = randomized controlled trial; TAU = treatment as usual

a

At post-intervention and at follow-up: rated down once for risk of bias due to serious concerns about the potential for bias arising from missing outcome data and bias in measurement of the outcomes (participant reported subjective outcomes); rated down once due to serious concerns for inconsistency because of limited of evidence of consistency as only 1 trial was available that reported on the outcome at all time points; rated down once due to serious concerns for indirectness because only 1 program (HOP/HOP-C) was identified and the population seemed relatively homogenous, thereby lowering the generalizability of findings to peer support programs in general; rated down once due to serious concerns about imprecision because of the relatively lower sample size in each comparison; publication bias was not detected.

From: Peer Support Programs for Youth Mental Health

Cover of Peer Support Programs for Youth Mental Health
Peer Support Programs for Youth Mental Health: Health Technology Assessment [Internet].
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