Table 10Summary of Findings by Outcome — Quality of Life

Study citation and design Study findings
Chaudhry et al. (2021)18

SR (1 RCT, Brisbe et al. 2014)

EQ-5D score

Difference in EQ-5D score between IV iron group and oral iron group was not significant

Independence index score

Difference in independence index score between IV iron group and oral iron group was not significant

Chaudhry et al. (2021)18

SR (1RCT, Yoo et al. 2019)

EQ-5D score

Difference in EQ-5D score between IV iron group and control group was not significant

Elhenawy et al. (2021)19

SR with MA (1 RCT, Bernabeu-Wittel et al. 2016)

SF36v2 at 60 days post-hospital discharge reassessment for IV iron therapy versus control

Results showed statistically non-significant changes between groups (measurements NR)

Elhenawy et al. (2021)19

SR with MA (1 RCT, Froessler et al. 2016)

SF36 at 4 weeks post-surgery reassessment for IV iron therapy versus control

Results showed statistically non-significant changes between groups (measurements NR)

Jones et al. (2021)20

SR (1 RCT, Khalafallah et al. 2016)

SF36 scores from postoperative day 1 to postoperative week 12a

IV iron group = 13.4

Standard of care group = 9.1

Physical scores from postoperative day 1 to postoperative week 12a

IV iron group = 13.4

Standard of care group = 7.9

Mental scores from postoperative day 1 to postoperative week 12a

IV iron group = 13.3

Standard of care group = 9.9

Jones et al. (2021)20

SR (1 RCT, Kim et al. 2017)

Mean fatigue scores at week 3 (95% CI)a

IV iron group = 30 (26.8 to 33.1)

Placebo = 34.6 (31.3 to 37.9)

Mean dyspnea scores at week 12 (95% CI)a

IV iron group = 9.5 (7.2 to 11.8)

Placebo = 14.2 (11.3 to 17.1)

Jones et al. (2021)20

SR (1 RCT, Richards et al. 2019)

Mean EQ-5D-5L Utility scores at 10 days, 8 weeks, and 6 months postoperative (SD)a

IV iron group = 0.80 (0.20); 0.79 (0.20); 0.82 (0.22)

Placebo group = 0.81 (0.21); 0.77 (0.21); 0.82 (0.21)

Mean EQ-5D-5L Health scores at 10 days, 8 weeks, and 6 months postoperative (SD)a

IV iron group = 70.6 (20.5); 70.7 (19.4); 75.0 (18.4)

Placebo group = 73.8 (19.6); 71.1 (19.5); 76.2 (19.2)

Mean MFI scores at 10 days, 8 weeks, and 6 months postoperative (SD)a

IV iron group = 53.2 (18.4); 52.9 (17.1); 48.8 (18.9)

Placebo group = 50.5 (18.9); 53.9 (17.7); 47.4 (19.1)

Fung et al. (2022)22

RCT

Median QOR-15 score (range)

IV iron group = 107 (100 to 124)

Control group = 115 (103 to 125)

P = 0.547

Kvaslerud et al. (2022)23

RCT

Mean EQ-5D3L index scores between IV iron group and placebo group at baseline and follow-up (range)

Mean IV iron group scores at baseline = 0.83 (0.77 to 0.93); Mean IV iron group scores at follow-up = 0.91 (0.82 to 0.97)

Mean placebo group scores at baseline = 0.81 (0.74 to 0.93); Mean placebo group scores at follow-up = 0.91 (0.78 to 0.97)

Mean difference (95% CI) = -0.001 (-0.4 to 0.4); P = 0.97

Mean EQ-5D VAS scores between IV iron group and placebo group at baseline and follow-up (range)

Mean IV iron group scores at baseline = 67 (50 to 80); Mean IV iron group scores at follow-up = 70 (48 to 84)

Mean placebo group scores at baseline = 50 (40 to 73); Mean placebo group scores at follow-up = 75 (60 to 85)

Mean difference (95% CI) = -7.8 (-16.5 to 0.86); P = 0.077

Thin et al. (2021)25

RCT

Mean EQ-5D-3L score at baseline between IV iron group (N = 15) and oral iron group (N = 15) (SD)

IV iron group = 70.3 (22)

Oral iron group = 73 (8)

P = 0.6

Mean EQ-5D-3L score at 1 month follow-up between IV iron group (N = 13) and oral iron group (N = 11) (SD)

IV iron group = 70.4 (21.8)

Oral iron group = 84.5 (12.1)

P = 0.07

Mean EQ-5D-3L score at 3-month follow-up between IV iron group (N = 13) and oral iron group (N = 11) (SD)

IV iron group = 80 (18.4)

Oral iron group = 85.9 (10.7)

P = 0.4

CI = confidence interval; EQ-5D = European Quality of Life – 5 Dimensions Questionnaire; EQ-5D-3L = European Quality of Life – 5 Dimension – 3 Levels; EQ-5D-5L = European Quality of Life – 5 Dimension – 5 Levels; IV = intravenous; MA = meta-analysis; MFI = Multidimensional Fatigue Inventory; NR = not reported; QOR-15 = 15-iten Quality of Recovery; RCT = randomized controlled trial; SD = standard deviation; SF36 = short form-36; SR = systematic review; VAS = visual analogue scale.

a

Statistical significance between groups was not provided by Jones et al. (2021)

From: Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update

Cover of Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update
Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update: Rapid Review [Internet].
Hill S, Severn M; Authors.
Copyright © 2022 Canadian Agency for Drugs and Technologies in Health.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.