Table 11Summary of Findings by Outcome — Days in Hospital or Recovery

Study citation and design Study findings
Jones et al. (2021)20

SR (1 RCT, Brisbe et al. 2014)

 Mean length of hospital stay, days (SD)a

IV iron group = 7.9 (1.7)

Oral iron group = 7.6 (0.9)

Jones et al. (2021)20

SR (1 RCT, Bernabeu-Wittel et al. 2016)

 Median length of hospital stay, days (range)a

IV iron group = 8 (6 to 11)

IV iron + EPO group = 7 (5 to 10)

Placebo group = 8 (6 to 10)

Jones et al. (2021)20

SR (1 RCT, Froessler et al. 2016)

 Median length of hospital stay, days (range)a

IV iron group = 6 (1 to 19)

No treatment group = 9 (1 to 23)

Jones et al. (2021)20

SR (1 RCT, Khalafallah et al. 2016)

 Mean length of hospital stay, days (SD)a

IV iron group = 7.8 (10.3)

Standard of care group = 11.6 (15.6)

Jones et al. (2021)20

SR (1 RCT, Keeler et al. 2017)

 Median length of hospital stay, days (range)a

IV iron group = 6 (5 to 10)

Oral iron group = 6 (4 to 9)

Jones et al. (2021)20

SR (1 RCT, Kim et al. 2017)

 Mean length of hospital stay, days (SD)a

IV iron group = 10.7 (7.9)

Placebo = 10.9 (13.8)

Jones et al. (2021)20

SR (1 RCT, Padmanabhan et al. 2019)

 Median length of hospital stay, days (range)a

IV iron group = 7 (6 to 12)

Oral iron group = 9 (6 to 14)

Jones et al. (2021)20

SR (1 RCT, Richards et al. 2019)

 Median length of hospital stay, days (range)a

IV iron group = 9 (7 to 14)

Placebo group = 9 (5 to 14)

Moon et al. (2021)21

SR (1 retrospective cohort study, Laso-Morales et al. 2018)

 Mean length of stay (days)

IV iron group = 9

Control group = 9

P = NS

Moon et al. (2021)21

SR (1 retrospective and prospective cohort study, Calleja et al. 2015)

 Mean length of stay (days)

IV iron group = 8.4

Control group = 10.9

P < 0.001

Moon et al. (2021)21

SR (1 prospective cohort study, Kam et al. 2020)

 Mean length of stay (days)

IV iron group = 9

Control group = 8.5

P = NS

Fung et al. (2022)22

RCT

 Median postoperative length of stay days (range)

IV iron group = 10 (5 to 19)

Control group = 7 (5 to 10)

P = 0.289

Days at home within 30 days of surgery (range)

IV iron group = 20 (10 to 15)

Control group = 23 (20 to 25)

P = 0.461

Shokri et al. (2022)24

RCT

 Length of hospital stay days between IV iron group and placebo group (SD)

IV iron group = 4.33 (1)

Placebo group = 8.68 (1.1)

P < 0.001

ICU stay days between IV iron group and placebo group (SD)

IV iron group = 1.28 (0.45)

Placebo group = 2.23 (0.95)

P < 0.001

Thin et al. (2021)25

RCT

 Mean total DAOH within 30 days between IV iron group and oral iron group (SD)

IV iron group = 19.3 (8.9)

Oral iron group = 18.6 (10.2)

P = 0.9

Mean total DAOH within 3 months between IV iron group and oral iron group (SD)

IV iron group = 75.2 (16.1)

Oral iron group = 68.8 (26.9)

P = 0.5

Mean total DAOH within 6 months between IV iron group and oral iron group (SD)

IV iron group = 166.8 (14.5)

Oral iron group = 270.7 (442)

P = 0.4

Ploug et al. (2022)26

Retrospective cohort study

 Median length of stay days between IV group and control group (range)

IV iron group = 4 (3 to 5)

Control group = 3.5 (3 to 5.5)

P = 0.74

Median DAOH 30-day follow-up between IV iron group and control group (range)

IV iron group = 26 (23 to 27)

Control group = 26 (24 to 27)

P = 0.997

Median DAOH 90-day follow-up between IV iron group and control group (range)

IV iron group = 86 (83 to 87)

Control group = 86 (82 to 87)

P = 0.79

Abdullah et al. (2021)27

Retrospective cohort study

 Mean length of stay days for 1:1 propensity matched IV iron group (N = 89) and oral iron group (N = 89) (SD)

IV iron group = 8 (12.5)

Oral iron group = 15.1 (23.6)

P = 0.013

Mean length of stay days for 1:2 propensity matched IV iron group (N = 89) and oral iron group (N = 178) (SD)

IV iron group = 8 (12.5)

Oral iron group = 14.1 (23.3)

P = 0.006

Evans et al. (2021)28

Retrospective cohort study

 Median length of stay days for each group (range)

IV treatment responsive group = 9 (6 to 41)

IV treatment unresponsive group = 11 (5 to 182); P < 0.001 vs non-anemic group

Untreated anemic group = 10 (3 to 53)

Non-anemic group = 8 (4 to 49)

Triphaus et al. (2021)31

Prospective cohort study

 Mean length of hospital stay days for each group (SEM)

Anemic, iron deficient and IV iron treatment group = 13.9 (0.8)

Iron deficient and IV iron treatment group = 14.9 (1.8)

Anemic and no treatment group = 16.7 (0.7)

Not anemic and no treatment group = 11.8 (0.3)

DAOH = days alive and out of hospital; EPO = erythropoietin; ICU = intensive care unit; IV = intravenous; MA = meta-analysis; NS = not significant; RCT = randomized controlled trial; SD = standard deviation; SR = systematic review.

a

Statistical significance between groups was not provided by Jones et al. (2021)

From: Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update

Cover of Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update
Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update: Rapid Review [Internet].
Hill S, Severn M; Authors.
Copyright © 2022 Canadian Agency for Drugs and Technologies in Health.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.