Table 13Summary of Findings by Outcome — Additional Clinical Outcomes

Study citation and design Study findings
Functional outcomes
Chaudhry et al. (2021)18

SR (1 RCT, Brisbe et al. 2014)

 6MWT score

Difference in 6MWT score between IV iron group and oral iron group was not significant

Chaudhry et al. (2021)18

SR (1RCT, Yoo et al. 2019)

 FACT-An score

Difference in FACT-An score between IV iron group and control iron group was not significant

Kvaslerud et al. (2022)23

RCT

 Mean 6MWT distance between IV iron group and placebo group at baseline and follow-up (SD)

Mean IV iron group baseline distance = 355 m (113); Mean IV iron group follow-up distance = 375 m (132)

Mean placebo group baseline distance = 367 m (129); Mean placebo group follow-up distance = 384 m (128)

Mean difference (95% CI) = 2 m (-21 to 25); P = 0.86

Ferritin Levels
Elhenawy et al. (2021)19

SR with MA (Based on 3 included studies)

 Ferritin level comparison at post-treatment and pre-surgery between IV iron and placebo or standard of care

Mean difference (95% CI) = 94.09 ng/ml (51.57 to 136.61); P < 0.0001

Ferritin level comparison at hospital discharge between IV iron and placebo or standard of care

Mean difference (95% CI) = 547.77 ng/ml (36.61 to 1058.94); P = 0.04

Ferritin level comparison > 4 weeks postoperative between IV iron and placebo or standard of care

Mean difference (95% CI) = 347.57 ng/ml (290.92 to 404.21); P < 0.0001

Ferritin level comparison at post-treatment and pre-surgery between IV iron and oral iron therapy

Mean difference (95% CI) = 106.12 ng/ml (32.46 to 179.78); P = 0.005

Fung et al. (2022)22

RCT

 Mean change in ferritin concentration from baseline to before surgery between IV iron therapy and control

Mean difference (95% CI) = 296.8 ng/L (200.6 to 393.2); P < 0.001

Kvaslerud et al. (2022)23

RCT

 Mean ferritin level from baseline to follow-up (SD)

Mean IV iron group ferritin level at baseline = 74.3 μg/L (57); Mean IV iron group ferritin level at follow-up = 361 μg/L (221)

Mean placebo group ferritin level at baseline = 69 μg/L (52); Mean placebo group ferritin level at follow-up = 79 μg/L (86)

Mean difference (95% CI) = 276 μg/L (216 to 336); P < 0.001

6MWT = 6-minute walk test; CI = confidence interval; FACT-An = Functional Assessment of Cancer Therapy for patients with Anemia/Fatigue; IV = intravenous; l = liter; m = meters; MA = meta-analysis; ml = milliliter; μg = microgram; ng = nanogram; NR = not reported; RCT = randomized controlled trial; SR = systematic review.

From: Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update

Cover of Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update
Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update: Rapid Review [Internet].
Hill S, Severn M; Authors.
Copyright © 2022 Canadian Agency for Drugs and Technologies in Health.

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