Table 17, Marginal Time and Treatment Effects for Claims-based Secondary Outcome Measures - Using Wellness Coaches and Extra Support to Improve the Health and Wellness of Adults with Serious Mental Illness

Outcomes	ICC: clinics, participants	Change over time from baseline	Least-squares estimates (95% CI)	Change by treatment from baseline	Least-squares estimates (95% CI)
Medication adherence: MPR for antipsychotics	0.000, 0.530	2.30 (4, 996)	.0569	--	0.82 (1, 9)	.3900	0.75 (0.61-0.89)	0.73 (0.57-0.88)
mo 0		--	--	0.75 (0.62-0.87)	--	--	--	--
mo 6		--	--	0.74 (0.61-0.87)	--	--	--	--
mo 12		--	--	0.75 (0.65-0.86)	--	--	--	--
mo 18		--	--	0.70 (0.56-0.85)	--	--	--	--
mo 24		--	--	0.75 (0.61-0.88)	--	--	--	--
Medication adherence: MPR for antidepressants	0.003, 0.579	1.58 (4, 1254)	.1772	--	4.41 (1, 9)	.0651	0.81 (0.74-0.89)	0.77 (0.67-0.87)
mo 0		--	--	0.79 (0.72-0.86)	--	--	--	--
mo 6		--	--	0.78 (0.70-0.87)	--	--	--	--
mo 12		--	--	0.81 (0.73-0.88)	--	--	--	--
mo 18		--	--	0.78 (0.69-0.88)	--	--	--	--
mo 24		--	--	0.79 (0.73-0.86)	--	--	--	--
Medication adherence: MPR for hypertension	0.000, 0.485	22.40 (4, 656)	< .0001^a	--	2.83 (1, 9)	.1267	0.71 (0.58-0.85)	0.68 (0.52-0.84)
mo 0		--	--	0.66 (0.52-0.79)	--	--	--	--
mo 6		--	--	0.68 (0.55-0.81)	--	--	--	--
mo 12		--	--	0.71 (0.57-0.86)	--	--	--	--
mo 18		--	--	0.72 (0.59-0.85)	--	--	--	--
mo 24		--	--	0.71 (0.60-0.83)	--	--	--	--
Laboratory monitoring: EKG services in 12 mo	0.000, 0.188	0.03 (2, 2144)	.9696	--	3.44 (1, 9)	.0966	0.13 (0.05-0.22)	0.11 (0.01-0.20)
mo 0		--	--	0.12 (0.05-0.19)	--	--	--	--
mo 12		--	--	0.12 (0.06-0.19)	--	--	--	--
mo 24		--	--	0.12 (0.01-0.23)	--	--	--	--
Laboratory monitoring: Lipid labs services in 12 mo	0.027, 0.440	7.86 (2, 2144)	.0004^a	--	2.08 (1, 9)	.1831	0.42 (0.09-0.75)	0.29 (0.08-0.50)
mo 0		--	--	0.31 (0.08-0.54)	--	--	--	--
mo 12		--	--	0.36 (0.14-0.59)	--	--	--	--
mo 24		--	--	0.39 (0.17-0.61)	--	--	--	--

Outcomes

ICC: clinics, participants

Change over time from baseline

Least-squares estimates (95% CI)

Change by treatment from baseline

Least-squares estimates (95% CI)

F value (df)

P value

F value (df)

P value

Medication adherence: MPR for antipsychotics

0.000, 0.530

2.30 (4, 996)

.0569

0.82 (1, 9)

.3900

0.75 (0.61-0.89)

0.73 (0.57-0.88)

mo 0

0.75 (0.62-0.87)

mo 6

0.74 (0.61-0.87)

mo 12

0.75 (0.65-0.86)

mo 18

0.70 (0.56-0.85)

mo 24

0.75 (0.61-0.88)

Medication adherence: MPR for antidepressants

0.003, 0.579

1.58 (4, 1254)

.1772

4.41 (1, 9)

.0651

0.81 (0.74-0.89)

0.77 (0.67-0.87)

mo 0

0.79 (0.72-0.86)

mo 6

0.78 (0.70-0.87)

mo 12

0.81 (0.73-0.88)

mo 18

0.78 (0.69-0.88)

mo 24

0.79 (0.73-0.86)

Medication adherence: MPR for hypertension

0.000, 0.485

22.40 (4, 656)

< .0001^a

2.83 (1, 9)

.1267

0.71 (0.58-0.85)

0.68 (0.52-0.84)

mo 0

0.66 (0.52-0.79)

mo 6

0.68 (0.55-0.81)

mo 12

0.71 (0.57-0.86)

mo 18

0.72 (0.59-0.85)

mo 24

0.71 (0.60-0.83)

Laboratory monitoring: EKG services in 12 mo

0.000, 0.188

0.03 (2, 2144)

.9696

3.44 (1, 9)

.0966

0.13 (0.05-0.22)

0.11 (0.01-0.20)

mo 0

0.12 (0.05-0.19)

mo 12

0.12 (0.06-0.19)

mo 24

0.12 (0.01-0.23)

Laboratory monitoring: Lipid labs services in 12 mo

0.027, 0.440

7.86 (2, 2144)

.0004^a

2.08 (1, 9)

.1831

0.42 (0.09-0.75)

0.29 (0.08-0.50)

mo 0

0.31 (0.08-0.54)

mo 12

0.36 (0.14-0.59)

mo 24

0.39 (0.17-0.61)

From: Using Wellness Coaches and Extra Support to Improve the Health and Wellness of Adults with Serious Mental Illness

Cover of Using Wellness Coaches and Extra Support to Improve the Health and Wellness of Adults with Serious Mental Illness

Using Wellness Coaches and Extra Support to Improve the Health and Wellness of Adults with Serious Mental Illness [Internet].

Schuster J, Reynolds C III, Carney T, et al.

Washington (DC): Patient-Centered Outcomes Research Institute (PCORI); 2019 Feb.

This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License which permits noncommercial use and distribution provided the original author(s) and source are credited. (See https://creativecommons.org/licenses/by-nc-nd/4.0/

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Table 17Marginal Time and Treatment Effects for Claims-based Secondary Outcome Measures