Table 2.

Cardiofaciocutaneous Syndrome: Frequency of Select Features

FeatureFrequencyComment
Nearly allCommonLess frequent
Prenatal polyhydramnios●
Characteristic facial features●
Cardiac issues●
Feeding difficulties●
Poor growth●
Skin issues●
Neurocognitive delays●Ranging from mild to profound
Eye anomalies●
Musculoskeletal abnormalities●
Hypotonia & motor developmental delay●
Seizures●
Behavioral issues●
Neonatal chylothorax &/or lymphedema●
Otolaryngologic issues●Most commonly recurrent otitis media
Urogenital anomalies●Most commonly cryptorchidism in males
Malignancy●
Hematologic issue●
Immunologic issues●

From: Cardiofaciocutaneous Syndrome

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