Table 5.

Treatment of Manifestations in Individuals with ARSACS

Manifestation/
Concern		TreatmentConsiderations/Other
Gait ataxia Physiotherapy, exergames tailored to ataxia [Schatton et al 2017]
Spasticity
  • PT & oral medication such as baclofen
  • Botulinum toxin injections
  • Orthotic devices
  • Use early in disease course may prevent tendon shortening & joint contractures.
  • May help to postpone major functional disabilities until severe muscle weakness or cerebellar ataxia occur
Intellectual
disability 		Adjust school services to degree of disability (which, when present, is typically mild).May require neuropsychological testing
Speech Evidence for the effectiveness of home-based speech therapy tailored to ARSACS dysarthria has been provided [Vogel et al 2019].
Hearing loss Hearing aids
Urinary
urgency 		Oral medication incl tolterodine, amitryptiline, or oxybutyninUrology referral

PT = physical therapy

From: ARSACS

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