Table 2.

Incidence of Select Clinical Manifestations by Multiple Endocrine Neoplasia Type 2 Phenotype

PhenotypeMedullary Thyroid CarcinomaPheochromocytomaParathyroid Disease
MEN2A 95%50%20%-30%
FMTC 100%<1% 1<1% 1
MEN2B 100%50%<1%

FMTC = familial medullary thyroid carcinoma; MEN2A = multiple endocrine neoplasia type 2A; MEN2B = multiple endocrine neoplasia type 2B

1.

FMTC is not associated with an increased risk for pheochromocytoma or parathyroid disease, and risk of pheochromocytoma and parathyroid disease are similar to the general population. Individuals with presumed FMTC who develop pheochromocytoma or parathyroid disease are instead more likely to have MEN2A.

From: Multiple Endocrine Neoplasia Type 2

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