Table 5a.

Recommended Surveillance Guidelines for Children and Adolescents with Peutz-Jeghers Syndrome

System/ConcernEvaluationFrequency
Gastrointestinal
polyps/cancer 		Colonoscopy & upper endoscopy
  • If the baseline endoscopy at age 8 yrs is negative, rpt at age 18 yrs.
  • If polyps are detected at baseline, endoscopy every 1-3 yrs based on size, number, & histopathology
Small-bowel exam by MRE or VCE
  • Every 1-3 yrs beginning at age 8 yrs
  • Or frequency based on findings; repeat at least by age 18 yrs. 1
Gynecologic
cancer 		Exam for precocious puberty in femalesAnnually beginning at age 8 yrs
Testicular
cancer
  • Testicular exam
  • Exam for feminizing changes in males
  • Testicular ultrasound exam if clinically indicated
Annually beginning at age 10 yrs

MRE = magnetic resonance enterography; VCE = video capsule endoscopy

1.

From: Peutz-Jeghers Syndrome

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