Table 2. [Alagille Syndrome: Frequency of Select Features]. - GeneReviews®

Feature	% of Persons w/Feature	Comment
Hepatic abnormality	95%	Bile duct paucity; conjugated hyperbilirubinemia; chronic cholestasis characterized by pruritus, xanthomas, & fat-soluble vitamin deficiencies; end-stage liver disease
Cardiac manifestations	90%-97%	Most commonly including peripheral pulmonary stenosis & tetralogy of Fallot
Posterior embryotoxon	78%-89%
Vertebral anomalies	33%-93%
Characteristic facies	20%-90%
Renal manifestations	39%	Renal malformations & kidney disease
Vascular	15%-30%	Intracranial bleeds, systemic vascular anomalies, & other, including moyamoya disease

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