Table 6.

Stickler Syndrome: Treatment of Manifestations

Manifestation/ConcernTreatmentConsiderations/Other
Respiratory Infants w/PRS may require tracheostomy to ensure a competent airway.In most persons, micrognathia tends to become less prominent over time, allowing for removal of tracheostomy.
Micrognathia Mandibular advancement procedure may be needed for persistent micrognathia to correct malocclusion.
Cleft palate Mgmt per craniofacial specialists incl feeding/nutrition mgmt
Ocular manifestations
  • Laser therapy for prevention of retinal detachment 1
  • Education on risk & symptoms of retinal detachment & need for immediate eval & treatment
  • Refractive errors should be corrected w/spectacles.
Hearing impairment
Early-onset arthropathy Symptomatic treatment incl over-the-counter anti-inflammatory medications before & after physical activityAt present, no prophylactic therapies to minimize joint damage in affected persons exist.
Spinal & other osteoarticular abnormalities Treatment per orthopedist

PRS = Pierre Robin sequence

1.

From: Stickler Syndrome

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