Table 4, Selectivity table showing IC50 (μM) values for ML252 and previously identified KCNQ2 channel blockers for inhibition of a panel of KCNQ channels measured using IonWorks electrophysiology - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf

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Table 4Selectivity table showing IC₅₀ (μM) values for ML252 and previously identified KCNQ2 channel blockers for inhibition of a panel of KCNQ channels measured using IonWorks electrophysiology

	IC₅₀ (μM)
Compound	KCNQ2	KCNQ1	KCNQ1/E1	KCNQ2/3	KCNQ4	KCNQ2 (published)^a
ML252	0.07 ± 0.01	2.92± 3.90	8.12± 1.47	0.12± 0.02	0.20± 0.06
XE-991	0.06 ± 0.01	0.40± 0.10	1.60± 0.17	0.31± 0.11	0.38± 0.15	0.71 ± 0.07
UCL2077	9.42± 1.12	0.06± 0.02	0.13± 0.12	>30	19.29± 11.3	4.8 ± 0.6
Linopirdine	0.71± 0.23	0.71± 0.28	2.08± 0.78	0.92± 0.14	1.68± 0.31	1.02

a: IC₅₀’s from published data were taken from [4][5]

From: Identification of a novel, small molecule inhibitor of KCNQ2 channels

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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