Table 7. [Recommended Surveillance for Individuals with Noonan Syndrome with Multiple Lentigines]. - GeneReviews®

System/Concern	Evaluation	Frequency
Growth	Measurement of growth parameters	At each visit
Cardiovascular	Cardiac auscultation to assess for new heart murmur
Echocardiogram	Annually until age 3 yrs, then at ages 5 yrs & 10 yrs or as clinically indicated
Hearing	Audiology eval	At least annually in infancy & childhood or as clinically indicated
Eyes	Ophthalmology eval	If nystagmus is noted or as clinically indicated
Neurologic	Assess for new manifestations such as seizure.	At each visit
Development	Monitor developmental progress & educational needs.
Family/ Community	Assess family need for social work support (e.g., palliative/respite care, home nursing, other local resources) & care coordination.

From: Noonan Syndrome with Multiple Lentigines

GeneReviews^® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

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