Table 5.

Recommended Evaluations Following Initial Diagnosis in Individuals with Hemophilia A

System/ConcernEvaluationComment
Hematologic
  • Personal & family history of bleeding to help predict disease severity
  • CBC w/platelet count, esp if history of nose bleeds, GI bleeding, mouth bleeding, or (in females) heavy menstrual bleeding or postpartum hemorrhage
  • Referral to HTC
  • F8 molecular testing to aid in determining disease severity, likelihood of inhibitor development, & testing of family members
Musculoskeletal Joint & muscle eval, esp if person reports history of hemarthrosis or deep-muscle hematomas
Infectious
disease 		Screening for hepatitis A, B, & C as well as HIV if blood products or plasma-derived clotting factor concentrates were administered prior to 1990
Genetic
counseling 		By genetics professionals 1To inform affected persons & their families re nature, MOI, & implications of hemophilia A to facilitate medical & personal decision making

CBC = complete blood count; GI = gastrointestinal; HTC = hemophilia treatment center; MOI = mode of inheritance

1.

Medical geneticist, certified genetic counselor, certified advanced genetic nurse

From: Hemophilia A

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