Table 5In vitro profile of ML247

CompoundAqueous Kinetic SolubilityMouse liver microsomal stability (% remaining after 60 min)Caco-2
(10−6 cm s−1)		Efflux Ratio
μMNo NADPHNADPHA to BB to A
ML247 (16)288.8100.6263.185.328.95.4
CID 44246394 (18)N/A104.592.0627.550.41.8
CID 1512045 (1)N/A4.324.322.331.413.4

From: Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase

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