Table 7a.

Recommended Minimum Surveillance for Individuals with MEN1

System/ConcernEvaluationFrequency
Parathyroid
tumors
  • Fasting total serum calcium concentration (corrected for albumin) &/or ionized-serum calcium concentration
  • Consider fasting serum concentration of intact (full-length) PTH.
Annually beginning at age 5 yrs 1
Anterior pituitary
adenomas 		Serum concentration of prolactin, IGF-1, fasting glucose, & insulinAnnually beginning at age 5 yrs 1
Head MRIEvery 3-5 yrs beginning at age 5 yrs 2
Well-differentiated
endocrine tumors
of the GEP tract 		Chromogranin-A, pancreatic polypeptide, glucagon, vasoactive intestinal peptide for other pancreatic neuroendocrine tumorsAnnually beginning at age 8 yrs 1
Fasting serum gastrin concentrationAnnually beginning at age 20 yrs 1
Consider abdominal CT, MRI, or EUS examEvery 3-5 yrs beginning at age 20 yrs 2
Carcinoid tumors Consider: 3
  • Chest CT;
  • Chest MRI;
  • SRS octreotide scan.
Consider annually beginning at age 15 yrs.
Non-endocrine
tumors 		Skin examConsider annually or as needed.

EUS = endoscopic ultrasound; GEP = gastroenteropancreatic; PTH = parathyroid hormone; SRS = somatostatin receptor scintigraphy

1.

International Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2 [Brandi et al 2001], and Clinical Practice Guidelines for MEN Type 1 [Thakker et al 2012]

2.

The interval depends on whether there is biochemical evidence of a neoplasia and/or signs and symptoms of a MEN1-related tumor.

3.

CT and MRI have better sensitivity than either chest x-ray or somatostatin receptor scintigraphy (SRS) scan in detecting either primary or recurrent thymic carcinoid [Gibril et al 2003, Scarsbrook et al 2007, Goudet et al 2009].

From: Multiple Endocrine Neoplasia Type 1

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