| Treatment | Generic Name | FDA Approval for RLS | Brand Name |
|---|---|---|---|
| Dopaminergic agents | Levodopa | No | Dopar® |
| Ropinirole | Yes | Requip® | |
| Pramipexole | Yes | Mirapex® | |
| Rotigotine patch | Yes | Neupro® | |
| Anticonvulsants (alpha-2-delta ligands) | Gabapentin enacarbil | Yes | Horizant® |
| Gabapentin | No | Neurontin® | |
| Pregabalin | No | Lyrica® | |
| Iron | Many formulations | No | - |
Sedative hypnotics and opioids were included in this review; however, no eligible studies assessed these agents in patients with RLS. Sedative hypnotics and opioids have not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of RLS.
From: Treatment for Restless Legs Syndrome
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