Table 3. [ALK-Related Neuroblastic Tumor Susceptibility: Recommended Evaluations Following Initial Diagnosis]. - GeneReviews®

System/Concern	Evaluation	Comment
Neuroblastic tumors	Physical exam to assess for clinical manifestations of neuroblastic tumors (e.g., abdominal mass, Horner syndrome, &/or cutaneous lesions)
Chest radiograph & abdominal ultrasound	Chest & abdomen are the most common sites for neuroblastic tumor development.
Measurement of urine catecholamine metabolite levels (homovanillic acid & vanillylmandelic acid)	May be ↑ in presence of neuroblastic tumor
Genetic counseling	By genetics professionals ¹	To inform affected persons & their families re nature, MOI, & implications of ALK-NTS to facilitate medical & personal decision making

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