Table 4:

Effects of Glucocorticoids on Blood Levels of Other Drugs (20)

DrugDrug blood levelsComments
AspirinDecreasedIncreased metabolism or clearance. Monitor salicylate level
Coumarin anticoagulantsDecreasedFrequent control of prothrombin levels
CyclophosphamideIncreasedInhibition of hepatic metabolism. Adjust the dosage
CyclosporineIncreasedInhibition of hepatic metabolism
InsulinDecreasedAdjust the dosage of the drug
IsoniazidDecreasedIncreased metabolism and clearance
Oral hypoglycemic agentsDecreasedAdjust the dosage of the drug

From: Glucocorticoid Therapy and Adrenal Suppression

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