| Author, Year | “A priori” design provided? | Duplicate study selection and data abstraction?
| Comprehensive literature search performed? | Non-English language studies considered for inclusion? | Conducted searches for unpublished (gray) literature? | List of included studies provided? | List of excluded studies provided with reasons? | Characteristics of the included studies provided? | Scientific quality of included studies:
| Sensitivity analyses or stratified analyses conducted according to study quality? | Study conclusions supported by the evidence? (Was study quality considered in the synthesis?) | Conflict of interest stated?
| Multidisciplinary systematic review team? | Quality Rating |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Carson, 2011 | Yes |
| Yes | No | No | Yes | No- only 4 of 38 excluded full text articles were listed in Appendix D | Yes |
| Qualitatively, yes | Yes |
| Unclear | Good |
| Chaparro, 2013 | Yes | Yes to both | Yes | Yes | No | Yes | Yes- but only for 36 of 76 excluded articles | Yes | Yes to both | No, except for analysis 4.1, examining results of studies with “enhanced enrollment”, meaning patients were enrolled only if they benefitted from opioids and tolerated side effects, then were randomized to opioid withdrawal. | Yes |
| Yes | Good |
Please see Appendix C. Included Studies for full study references.
From: Appendix F, Quality Assessment
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