Some major parasites and their glycan-binding proteins
| Parasite | Stage | Protein | Specificity |
|---|---|---|---|
| Plasmodium falciparum | merozoite | EBA-175 | Neu5Acα2-3Gal/glycophorin A |
| merozoite | EBA-140 | sialic acid/glycophorin B? | |
| merozoite | EBA-180 | sialic acid | |
| sporozoite | circumsporozoite protein | HS | |
| parasitized erythrocytes | the anchor protein VAR2CSA | chondroitin sulfate A | |
| Trypanosoma cruzi | trypomastigote | trans-sialidase | Neu5Acα2-3Gal |
| trypomastigote | penetrin | HS | |
| Entamoeba histolytica | trophozoite | Gal/GalNAc lectin | Gal/GalNAc |
| Entamoeba invadens (a reptilian pathogen) | cyst | cyst wall protein (Jacob lectin) | chitin |
| Giardia lamblia | trophozoite | taglin (α-1 giardin) | Man-6-PO4-, HS |
| Cryptosporidium parvum | sporozoite | Gal/GalNAc lectin | Gal/GalNAc |
| sporozoite | Cpa135 protein | ? | |
| Acanthamoeba keratitis | trophozoite | 136 kDa mannose-binding protein | mannose |
| Toxocara canis | larval | TES-32 | ? |
| Haemonchus contortus | gut-localized | galectin (Hco-gal) | β-galactosides |
HS, heparan sulfate.
From: Chapter 43, Parasitic Infections
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