Table 5.

Prevention of Primary Manifestations in Individuals with Congenital Insensitivity to Pain

Manifestation/ConcernPreventionConsiderations/Other
Injuries occurring around the home Stair gates; soft-round edging on tables & protruding objects; guard all heating devices; close supervision of younger children in the kitchen
Injuries occurring at school Inform personnel at school of diagnosis; seek help when accident occurs but child does not seem hurt.
Self-inflicted injuries Education of affected individuals about their condition.Communicating w/other families of individuals w/CIP (especially affected adults)
Corneal abrasion At least annual ophthalmologic eval; artificial tears
  • Artificial tears are particularly helpful to those w/PRDM12-CIP.
  • All persons w/congenital corneal anesthesia have had SCN9A-CIP [Author, personal observation].
Staphylococcus aureus infections
  • Good hand hygiene & care; use of antiseptic soaps; early use of topical antibiotics
  • Investigation of swollen joints, limping, & limb underuse for infection by radiograph & C-reactive protein
Affects those w/NTRK1-, NGF-, CLTCL1-, & PRDM12-CIP; infections are specific for S aureus only.

From: Congenital Insensitivity to Pain Overview

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