Table 6. [Prevention of Secondary Manifestations in Individuals with Congenital Insensitivity to Pain]. - GeneReviews®

Manifestation/Concern	Prevention	Considerations/Other
Inability to use pain as indicator in diagnosing or assessing injury severity	Laminated information letters/MediAlert bracelets	Consider providing laminated letter confirming diagnosis, stating pathogenic variant(s), & giving advice on diagnosis & treatment.
Osteomyelitis of mandible	Early treatment of dental caries & periodontal disease	Regular dental exams & restriction of sweets
Bone & joint injury due to strenuous activity when individual has poor baseline conditioning	Activities that lead to increased strength, balance, & body awareness	Dancing (particularly ballet), swimming, cycling, & non-traumatic martial arts may be considered.
Inadequate sedation in postoperative period may trigger unexpected movement, causing secondary injury.	Adequate sedation during procedures	Tachycardia & hypertension in postoperative period should raise consideration of the possibility of inadequate sedation.
Hyper- or hypothermia	Careful monitoring of temperature during perioperative period

From: Congenital Insensitivity to Pain Overview

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