Table E-1Thresholds for clinical significance

Instrument/OutcomeRange (points)Final scoreThreshold
ACT5 to 25Well-controlled: ≥20
Not well-controlled: ≤19
≥12 y: Δ 3 points1
ACQ5, ACQ60 to 6Uncontrolled: ≥1.5
Well-controlled: <0.75
≥18 y: Δ 0.5 points2
ACQ70 to 6Uncontrolled: ≥1.5
Well-controlled: <0.75
≥6 y: Δ 0.5 points2,3
AQLQ, AQLQ(S), AQLQ-mini1 to 7Severe impairment = 1
No impairment= 7
≥18 y: Δ 0.5 points46
AQLQ12+1 to 7Severe impairment = 1
No impairment= 7
≥12 y: Δ 0.5 points7,8
PAQLQ, PACQLQ1 to 7Severe impairment = 1
No impairment= 7
7–17 y: Δ 0.5 points9,10
FEV1Continuous measure, LNA≥18 y: −0.2 L11
Rescue medication useContinuous measure, puffs per unit of timeNA≥18 y: −0.81 puffs/day11

From: Appendix E, Minimally Important Differences

Cover of Effectiveness of Indoor Allergen Reduction in Management of Asthma
Effectiveness of Indoor Allergen Reduction in Management of Asthma [Internet].
Comparative Effectiveness Reviews, No. 201.
Leas BF, D’Anci KE, Apter AJ, et al.

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