Table 11Studies included in KQ 3 network meta-analysis

Treatment ComparisonStudy NameOverall D/CaD/C due to AEsa
ABA + MTX vs. MTXAGREE, 2009,31 2011,129, 130 2015131XX
ABA + MTX vs. ABA vs. MTXAVERT, 20157XX
ADA + MTX vs. MTXPROWD, 2008,16 2016152XX
CZP + MTX vs. MTXC-EARLY, 201738, 39XX
CZP + MTX vs. MTXC-OPERA, 2016,13 2017153XX
ETN vs. MTXEnbrel ERA, 2000,14 2002,110 2005,164 2006111XX
ETN + MTX vs. MTXCOMET, 2008,12 2009,154 2010,108, 109 2012;155 2014,156XX
IFX + MTX vs. MTXASPIRE, 2004,17 2006,107 2009,106 2017157XX
IFX + MTX vs. Methyl-PNL + MTX vs. MTXDurez et al., 200718XX
IFX + MTX vs. MTXQuinn et al., 200541X
SSZ + MTX vs. SSZ vs. MTXDougados et al., 1999;21 Maillefert et al., 2003104XX
SSZ + MTX vs. SSZ vs. MTXHaagsma et al., 199723XX
TCZ + MTX vs. TCZ vs. MTXFUNCTION, 2016,32 2017134XX
TCZ + MTX vs. TCZ vs. MTXU-Act-Early, 201633XX
a

All data used in NWMA were measured at the 1-year followup time point.

ABA = abatacept; ACR50 = American College of Rheumatology 50% improvement; ADA = adalimumab; AE = adverse event; AGREE = Abatacept trial to Gauge Remission and joint damage progression in methotrexate-naïve patients with Early Erosive rheumatoid arthritis; ASPIRE = Active-controlled Study of Patients receiving Infliximab for the treatment of Rheumatoid arthritis of Early onset trial; AVERT = Assessing Very Early Rheumatoid arthritis Treatment trial; C-EARLY = trial whose acronym not described; C-OPERA = Certolizumab-Optimal Prevention of joint damage for Early RA trial; COMET = Combination of Methotrexate and Etanercept in Active Early Rheumatoid Arthritis trial; CZP = certolizumab pegol; D/C = discontinuation; Enbrel ERA = Enbrel Early RA trial; ETN = etanercept; FUNCTION = trial whose acronym not described; IFX = infliximab; KQ = Key Question; methyl-PNL = methylprednisolone; MTX = methotrexate; NA = not applicable; NWMA = network meta-analysis; RA = rheumatoid arthritis; SSZ = sulfasalazine; TCZ = tocilizumab; U-Act-Early = Trial whose acronym not described; vs. = versus.

From: Results

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 211.
Donahue KE, Gartlehner G, Schulman ER, et al.
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