Table I-3Metacognitive therapy compared with inactive controls (waitlist or usual care)

Domains Pertaining to Strength of EvidenceMagnitude of EffectStrength of Evidence
Number of Studies;
Number of Subjects
Risk of Bias; DesignConsistencyDirectnessPrecisionSummary Effect Size (95% CI)High, Moderate, Low, Insufficient
PTSD Symptom Reduction: mean change from baseline to end of treatment
1; 21Medium; RCTsNA, single studyDirectImpreciseWMD −27.7Insufficient
Prevention/reduction of comorbid depression: mean change from baseline to end of treatment in BDI
1; 21Medium; RCTsNA, single studyDirectImpreciseFindings favor MCT, p<0.05Insufficient
Prevention/reduction of comorbid anxiety: mean change from baseline to end of treatment in BAI
1; 21Medium; RCTsNA, single studyDirectImpreciseFindings favor MCT, p<0.05Insufficient

BAI = Beck Anxiety Inventory; CI = confidence interval; NA = not applicable; NNT = number needed to treat; RCT = randomized controlled trial; RD = risk difference; WL = waitlist.

From: Appendix I, Strength of Evidence

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.

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