Table I-33, Strength of evidence for divalproex compared with placebo - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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	Domains Pertaining to Strength of Evidence				Magnitude of Effect	Strength of Evidence
Number of Studies; Number of Subjects	Risk of Bias; Design	Consistency	Directness	Precision	Summary Effect Size (95% CI)	High, Moderate, Low, Insufficient
PTSD Symptom Reduction: CAPS
1; 85	Low; RCT	NA, single study	Direct	Imprecise	WMD −1.40, p=ns	Insufficient
Prevention/reduction of comorbid depression: MADRS
1; 85	Low; RCT	NA, single study	Direct	Imprecise	WMD −0.6, p=ns	Insufficient
Prevention/reduction of comorbid anxiety: HAM-A
1; 85	Low; RCT	NA, single study	Direct	Imprecise	WMD 1.4, p=ns	Insufficient

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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