Table I-34Strength of evidence for tiagabine compared with placebo

Domains Pertaining to Strength of EvidenceMagnitude of EffectStrength of Evidence
Number of Studies;
Number of Subjects		Risk of Bias; DesignConsistencyDirectnessPrecisionSummary Effect Size (95% CI)High, Moderate, Low, Insufficient
PTSD Symptom Reduction: CAPS
1; 232Medium; RCTNA, single studyDirectImpreciseWMD −0.50, p-nsInsufficient
Remission (CAPS less than 20)
1; 232Medium; RCTNA, single studyDirectImpreciseRD 0.02, p=nsInsufficient
Disability/functional impairment: Sheehan Disability Scale
1; 232Medium; RCTNA, single studyDirectImpreciseWMD 0.4, p=nsInsufficient

From: Appendix I, Strength of Evidence

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].
Comparative Effectiveness Review, No. 207.
Forman-Hoffman V, Middleton JC, Feltner C, et al.
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