Table I-44, Placebo-controlled trials of mirtazapine - Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update

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	Domains Pertaining to Strength of Evidence				Magnitude of Effect	Strength of Evidence
Number of Studies; Number of Subjects	Risk of Bias; Design/Quality	Consistency	Directness	Precision	Summary Effect Size (95% CI)	High, Moderate, Low, Insufficient
PTSD Symptom Reduction: DTS
1; 29	Medium; RCT	NA, single study	Direct	Imprecise	WMD −9.5, p=ns	Insufficient
PTSD Symptom Reduction: SPRINT
1; 29	Medium; RCT	NA, single study	Direct	Imprecise	WMD −3.76, p=ns	Insufficient
PTSD Symptom Reduction: SIPS
1; 29	Medium; RCT	NA, single study	Direct	Imprecise	WMD −10.8, p<0.05	Insufficient
Prevention/reduction of comorbid depression: HADS-D
1; 29	Medium; RCT	NA, single study	Direct	Imprecise	WMD −1.7, p=ns	Insufficient
Prevention/reduction of comorbid anxiety: HADS-A
1; 29	Medium; RCT	NA, single study	Direct	Imprecise	WMD −1.6, p<0.05	Insufficient

Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 207.

Forman-Hoffman V, Middleton JC, Feltner C, et al.

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